Azithromycin is generally a safe drug. Drinking moderate amounts of alcohol (three drinks or fewer per day) doesn’t seem to reduce the effectiveness of this drug. However, combining azithromycin. While azithromycin does not have the same severe interactions with alcohol that some other antibiotics do, combining alcohol with azithromycin can still cause problems. Alcohol can increase side effects such as nausea, dizziness, and stomach upset that may already occur with azithromycin. You can safely drink alcohol while taking azithromycin, as there is no direct pharmacological interaction between the two, though alcohol may worsen gastrointestinal side effects. Although Azithromycin avoids the severe disulfiram-like effect, combining it with alcohol increases the likelihood and severity of shared physical side effects. Both Azithromycin and alcohol commonly cause gastrointestinal upset, including nausea, vomiting, stomach pain, and diarrhea. Official answer: There are no known interactions between Azithromycin (Zithromax Z-Pak) and alcohol so you could take a glass or two if. I have been prescribed azithromycin and I'm wondering if it's OK to drink alcohol occasionally? There are no known interactions between Azithromycin (Zithromax Z-Pak) and alcohol so you could take a glass or two if you wanted to. Alcohol: There's no direct interaction between Azithromycin and alcohol. However, alcohol can worsen side effects like nausea and diarrhea, and it impairs immune function. Azithromycin (Zithromax) is an antibiotic. Combining azithromycin with alcohol may not be advisable when the body is fighting an infection. It could also make side effects worse. Consuming alcohol while taking Azithromycin does not pose an immediate threat of this specific toxic reaction. While there is no direct chemical toxicity, combining any medication with alcohol is strongly discouraged by most healthcare professionals. It is generally considered safe to drink alcohol in moderation while taking azithromycin. Alcohol does not appear to reduce the effectiveness of azithromycin nor cause dangerous interactions.